Research Articles
Biocatalytic vs Chemical Processes: A Life Cycle Assessment Guide for Sustainable Pharmaceutical Development
This article provides researchers, scientists, and drug development professionals with a comprehensive analysis of Life Cycle Assessment (LCA) methodologies for comparing biocatalytic and chemical manufacturing processes.
From Algorithm to Lab Bench: A Researcher's Guide to Validating Machine Learning Predictions for Enzyme Activity
This article provides a comprehensive framework for researchers and drug development professionals to rigorously validate machine learning predictions of enzyme activity.
Immobilized Enzymes vs. Free Enzymes: A Comprehensive Performance Evaluation for Biomedical and Industrial Applications
This article provides a critical evaluation of immobilized enzyme performance compared to their free counterparts, tailored for researchers and drug development professionals.
Benchmarking De Novo Designed Enzymes: Evaluating AI-Generated Proteins Against Natural Counterparts
This article provides a comprehensive analysis of the current state and critical challenges in benchmarking de novo designed enzymes against their natural counterparts.
Directed Evolution vs. Rational Design: A Strategic Guide for Protein Engineering in Drug Development
This article provides a comprehensive comparison of directed evolution and rational design, the two dominant strategies in protein engineering.
Harnessing Electric Fields for Next-Generation Enzyme Design: From Electrostatic Principles to Biomedical Applications
This article explores the critical role of optimizing intrinsic electric fields for the design of efficient artificial enzymes.
Strategies for Improving Enzyme Solubility and Reducing Aggregation in Biotherapeutic Development
This article provides a comprehensive resource for researchers and drug development professionals tackling the critical challenges of enzyme solubility and aggregation.
Machine Learning to Navigate Protein Fitness Landscapes: A Comprehensive Guide for Researchers and Drug Developers
This article provides a comprehensive overview of how machine learning (ML) is revolutionizing the navigation of protein fitness landscapes to accelerate protein engineering.
Dynamic Regulation of Metabolic Pathways in Engineered Cells: From Biosensor Circuits to Intelligent Biomanufacturing
This article provides a comprehensive overview of dynamic regulation strategies for metabolic pathways in engineered microbial cells, a pivotal advancement in synthetic biology and metabolic engineering.
Computational Protein Stability Design: Preventing Misfolding and Aggregation for Therapeutics
This article provides a comprehensive overview of modern strategies for designing protein stability to prevent misfolding and aggregation, a key pathological mechanism in neurodegenerative diseases and loss-of-function disorders.