Research Articles
De Novo Enzyme Design: Overcoming Core Challenges in Computational Protein Engineering
This article provides a comprehensive analysis of the current challenges and solutions in de novo enzyme design.
Beyond Static Models: Conquering Active Site Flexibility for Next-Generation Computational Enzyme and Drug Design
This article provides a comprehensive guide for researchers and drug development professionals on addressing the critical challenge of active site flexibility in computational designs.
Excipients & Additives Guide: Preventing Protein Aggregation in Biotherapeutics
This article provides a comprehensive review for researchers and drug development professionals on the strategic use of excipients and additives to prevent protein aggregation.
Enzyme Stabilization Strategies: A Comprehensive Guide to Additives and Compatible Solutes for Biomedical Research
This article provides researchers and drug development professionals with a comprehensive, evidence-based guide to stabilizing enzymes using additives and compatible solutes.
Unlocking Novel Biocatalysts: A Comprehensive Guide to Metagenomic Library Screening for Carboxylesterase Activity
This article provides a detailed roadmap for researchers and biotechnologists seeking to discover novel carboxylesterases from uncultured microbial communities.
Active Site Repacking Algorithms: Transforming Enzyme Design and Catalytic Optimization in Drug Discovery
This comprehensive article explores the cutting-edge computational field of active site repacking algorithms, essential tools for the de novo design and optimization of enzyme catalysts.
Active Site Preorganization Strategies: Mastering Conformational Control for Next-Generation Drug Design
This comprehensive review explores the fundamental principles and advanced applications of active site preorganization strategies in enzyme engineering and drug discovery.
Beyond Active Sites: How Preorganization Strategies Are Revolutionizing Artificial Enzyme Design for Biomedical Applications
This article provides a comprehensive analysis of active site preorganization as a critical design principle in artificial enzyme engineering.
Active Site Labeling Techniques: A Comprehensive Guide for Enzyme Mechanism Studies and Drug Discovery
This article provides researchers, scientists, and drug development professionals with an in-depth exploration of contemporary active site labeling techniques for enzyme studies.
Accelerating Enzyme & Protein Engineering: How Active Learning Revolutionizes Directed Evolution of Epistatic Residues
This article provides a comprehensive guide for researchers on integrating active learning with directed evolution to efficiently engineer proteins with complex epistatic interactions.