Research Articles
Abiotic Catalysis in Living Systems: Beyond Enzymes to Novel Therapeutics
This article explores the emerging paradigm of abiotic reaction catalysis within living organisms.
ZymCtrl LLM: The AI-Powered Enzyme Generator for Drug Discovery and Synthetic Biology
This article provides a comprehensive guide to ZymCtrl, a specialized large language model (LLM) for generating novel enzymes directly from EC (Enzyme Commission) numbers.
The Warshel Theory of Electrostatic Preorganization: Decoding Enzyme Catalysis for Drug Discovery and Design
This article provides a comprehensive guide for researchers and drug development professionals on the application and implications of Arieh Warshel's theory of electrostatic preorganization in enzyme catalysis.
UniKP: The AI Framework Revolutionizing Enzyme Kinetic Parameter (kcat/Km) Prediction for Drug Discovery
This article provides a comprehensive guide to the UniKP framework, a unified deep learning model for predicting enzyme kinetic parameters (kcat and Km).
TIM Barrel Proteins: Engineering the Ultimate Catalytic Scaffold for Diverse Enzymatic Reactions
This review comprehensively explores the TIM barrel, one of nature's most versatile and evolutionarily successful protein folds, as a scaffold for diverse catalytic functions.
Automating Enzyme Discovery: A Comprehensive Snakemake Workflow for Targeted Metagenomic Screening
This article provides a complete guide for researchers and drug discovery professionals on implementing a reproducible Snakemake workflow for targeted enzyme discovery.
STRENDA Guidelines for Enzyme Kinetics: Essential Reporting Standards for Reproducible Research and Drug Discovery
This article provides a comprehensive guide to the STRENDA (Standards for Reporting Enzymology Data) guidelines, essential for researchers, scientists, and drug development professionals.
STRENDA DB: The Definitive Guide to Validating Enzyme Kinetics Data for Reproducible Research and Drug Discovery
This comprehensive guide explores the STRENDA DB (Standards for Reporting Enzymology Data) database and its critical role in validating enzyme kinetics data.
Unlocking Cellular Drug Targets: A Comprehensive Guide to System-Wide Substrate Identification with SIESTA Thermal Profiling
This article provides a complete framework for researchers and drug development professionals on implementing and applying the Stability of Proteins from Rates of Oxidation (SIESTA) thermal profiling technique.
RosettaDesign vs RFdiffusion: Comparing the Leading AI Tools for De Novo Enzyme Engineering in 2024
This article provides a comprehensive, comparative analysis of two dominant computational platforms for de novo enzyme design: RosettaDesign and RFdiffusion.