Research Articles
The Brønsted-Evans-Polanyi Principle in Enzymology: From Theory to Drug Discovery Applications
This article explores the application and significance of the Brønsted-Evans-Polanyi (BEP) relationship in enzyme catalysis.
Accelerating Protein Engineering: A Practical Guide to Bayesian Optimization for Drug Discovery
This article provides a comprehensive guide to Bayesian Optimization (BO) for protein engineering, targeting researchers, scientists, and drug development professionals.
SABIO-RK vs. BRENDA Database Comparison: Choosing the Right Tool for Enzyme Kinetics Research
This comprehensive analysis compares the two primary public repositories for enzyme kinetics data, BRENDA and SABIO-RK.
Unlocking Enzyme Flexibility: A Comprehensive Guide to B-Factor Analysis for Dynamic Region Identification
This article provides researchers, scientists, and drug development professionals with a complete framework for using B-factor (temperature factor) analysis to identify flexible and dynamic regions in enzyme structures.
From Principle to Practice: Anfinsen's Dogma as the Blueprint for Modern De Novo Protein Design
This article explores the foundational principles, computational methodologies, and cutting-edge applications of de novo protein design, firmly rooted in Anfinsen's thermodynamic hypothesis.
AlphaFold2 vs RoseTTAFold: A Comparative Analysis of Accuracy, Methods, and Impact on Drug Discovery
This article provides a comprehensive and up-to-date comparison of AlphaFold2 and RoseTTAFold, the two leading AI systems for protein structure prediction.
AlphaFold2 Protocol Guide: From Prediction to Validation for Drug Discovery Researchers
This comprehensive guide provides researchers, scientists, and drug development professionals with a detailed, step-by-step protocol for AlphaFold2 protein structure prediction.
AlphaFold2 Revolutionizes Enzyme Engineering: From Structure Prediction to Rational Design in Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on leveraging AlphaFold2 for enzyme science.
AlphaFold2 Beyond Structure: Revolutionizing Enzyme Function Annotation for Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on utilizing AlphaFold2 for accurate enzyme function annotation.
Revolutionizing Biologics: How AI-Driven Excipient Selection is Transforming Enzyme Formulation Stability
This article provides a comprehensive overview of the paradigm shift towards artificial intelligence (AI) in the selection of excipients for enzyme-based drug formulations.